Methylation, Folate & One-Carbon Metabolism

This report may be useful if you experience any of these:

Methylation is a job your body does billions of times a second — attaching tiny chemical tags that switch genes on and off, clear histamine and estrogen, build neurotransmitters, protect your liver, and repair DNA. When it runs slow (or, for some people, too fast), symptoms show up across many systems at once. This report combines your DNA with your symptoms to find the weak link across the folate cycle, methionine cycle, B12 handling, choline, and the sulfur arm — and closes with a Support-Strategy page that matches the right form to you (methylfolate vs folinic acid, methyl- vs hydroxocobalamin), because the wrong form is a common reason methylation support backfires.

• Fatigue, low motivation, slow recovery
• Low mood, anxiety, irritability, mood swings
• Brain fog, slow word-finding or processing
• Histamine intolerance (flushing, hives, food/wine reactions)
• Estrogen-dominance: PMS, breast tenderness, fibroids
• Elevated homocysteine
• Tingling, numbness, or restless legs
• "Normal" B12 but still feeling deficient
• Fatty liver or gallbladder problems
• Reactions to garlic, wine, or sulfite foods
• Feeling worse on methylfolate or methyl-B12
• Premature graying; reactivity to alcohol
• History of miscarriage or pregnancy complications
• Sensitivity to nitrous oxide (dental gas)

Answer the questions below as honestly as you can. Combined with your DNA file, your answers map which part of your methylation system most needs support — and, importantly, which supplement form is most likely to help rather than backfire.