Drug Metabolism & Pharmacogenomics
How your genes shape your response to medications, caffeine, alcohol, and hormones.
This report may be useful if you experience any of these symptoms:
Every medication you take must be processed - activated, broken down, conjugated, and excreted. The genes in this report build the machinery that does that. They also handle hormones, caffeine, alcohol, and many environmental chemicals. Common variants explain why two people on the same dose of the same drug can have very different experiences - one person gets full relief, another gets none, a third gets severe side effects. This is the real biological basis of "sensitive to medications."
- Caffeine: jittery, palpitations, or sleep-disrupted by small doses
- Caffeine has little effect on you, even at high doses
- Sensitive to medications generally; lower doses work for you
- Need higher-than-usual doses for medications to work
- Bad reactions to common SSRIs, TCAs, or antipsychotics
- Codeine or tramadol gave little to no pain relief
- Codeine or tramadol caused severe drowsiness or nausea
- Statin-related muscle pain even at low doses
- Clopidogrel (Plavix) seemed ineffective after a stent
- Warfarin needed unusual dosing or had bleeding events
- PPIs (omeprazole, esomeprazole) cause many side effects
- Gilbert's syndrome - mild jaundice with stress, fasting, illness
- Sensitive to acetaminophen at standard doses
- Alcohol makes other medications behave oddly
- Sensitive to phenolic foods (sulfites, artificial colors, salicylates)
- Strong reactions to fragrances, smoke, exhaust, chemicals
- Estrogen-driven symptoms (PMS, fibroids, endometriosis)
- Family history of breast, endometrial, or prostate cancer
- Gout or hyperuricemia, especially at younger age
- Tendency to bleed easily on NSAIDs
- Slow recovery from anesthesia, or anesthesia awareness
- Postpartum drug clearance changed noticeably
- Family history of 5-FU or capecitabine toxicity
- Drug-induced lupus (joint pains, facial rash, +ANA)
Worth knowing: Some genes here change how specific medications work - codeine, tramadol, warfarin, clopidogrel, simvastatin, and 5-FU/capecitabine all have CPIC clinical guidelines. Always disclose your pharmacogenomic information to every prescriber and pharmacist; never change a medication based on this report alone.
Answer the symptom questions below as honestly as you can. Combined with your DNA file, your answers help map which pathways are most worth your attention, and which support strategies give you the highest leverage.
Your Information
Click to choose your DNA file, or drag and drop it here
Accepted: .txt, .csv, .zip— file stays private and is deleted after your report is generated
Once you submit, your personalized PDF report will be generated and emailed to you, typically within a few minutes. Please check your spam folder if it doesn't arrive.
This report is for educational purposes only and is not medical advice. It does not replace clinical pharmacogenomic testing or pharmacist review. Do NOT start, stop, or change any medication based on this report. Patients facing 5-FU or capecitabine chemotherapy should specifically discuss DPYD testing with their oncologist. Always disclose all medications, supplements, and herbs to every prescriber.