Connective Tissue, EDS & Collagen
How your genes shape collagen strength, elastic tissue, joint stability, and bone.
This report may be useful if you experience any of these symptoms:
Connective tissue is your body's scaffolding — collagen (the strong, rope-like protein, about 30% of all the protein in you), elastin (the stretchy one), and a gel-like cushioning matrix. It is in skin, tendons, ligaments, joint capsules, blood vessel walls, the gut wall, bone, cartilage, and heart valves. When the genes that build or maintain it carry variants, tissue can be too loose, too fragile, slow to heal, or prone to scarring — the Ehlers-Danlos syndromes are the best-known example. Many people with connective tissue differences also have a striking cluster of dysautonomia (POTS), mast cell activation, and gut dysmotility. This report maps which part of your connective tissue most needs support.
- Joints that bend beyond the normal range
- Joint subluxations or dislocations
- Chronic, often widespread joint and muscle pain
- Early-onset osteoarthritis
- Soft, velvety, stretchy, or fragile skin
- Easy bruising, poor wound healing, wide thin scars
- Frequent sprains, strains, and soft-tissue injuries
- Flat feet, scoliosis, chest-wall deformities
- Hernias (inguinal, umbilical, hiatal)
- Pelvic floor dysfunction or prolapse
- POTS, lightheadedness, exercise intolerance
- Flushing, hives, food or chemical reactions
- Reflux, slow gut motility, bloating, constipation
- Chronic fatigue
- Anxiety (overrepresented in hypermobile EDS)
- TMJ dysfunction, jaw clicking and pain
- Dental crowding, high palate, gum recession
- Headaches, including cervicogenic types
- Varicose veins at a young age
- Stretch marks unrelated to weight change
- Cold hands and feet, Raynaud-like symptoms
- Poor proprioception, clumsiness, frequent falls
- Slow surgical recovery, anesthesia sensitivity
- Family history of a connective tissue disorder
Please read: Some connective tissue conditions are serious. A personal or family history of arterial aneurysm, arterial or organ rupture, aortic enlargement, or sudden unexplained death at a young age can point to vascular EDS, Marfan syndrome, or Loeys-Dietz syndrome. These need urgent evaluation by a geneticist and cardiologist. This questionnaire and report are educational tools — they do not diagnose these conditions and are not a substitute for specialist medical care.
Answer the symptom questions below as honestly as you can. Combined with your DNA file, your answers help map which part of your connective tissue is most worth your attention, and which support strategies give you the highest leverage.
Your Information
Click to choose your DNA file, or drag and drop it here
Accepted: .txt, .csv, .zip— file stays private and is deleted after your report is generated
Once you submit, your personalized PDF report will be generated and emailed to you, typically within a few minutes. Please check your spam folder if it doesn't arrive.
This report is for educational purposes only and is not medical advice. It does not diagnose Ehlers-Danlos syndrome, Marfan syndrome, Loeys-Dietz syndrome, or any other condition. Features suggesting aneurysm, arterial or organ rupture risk, or aortic disease require urgent evaluation by a qualified physician. Consult your healthcare provider before changing supplements, medications, or exercise.